Figure 2
From: Promising targets of cell death signaling of NR2B receptor subunit in stroke pathogenesis
Blockade of NMDA receptor or NMDA-DAPK1 downstream signaling induces different fates of neuronal cells in stroke. (A) Blockade of NMDA receptor in stroke causes 1) inhibition of necrosis, apoptosis and autophagy of neuronal cells; 2) suppression of endogenous surviving and regeneration signaling; 3) interruption of physiological functions of synaptic transmission. (B) Blockade of NMDA(NR2B)-DAPK1 downstream signaling in stroke specifically mediates 1) prevention of cell death (such as necrosis, apoptosis and autophagy); 2) probable inhibition of cell survival; and 3) no adverse effects on physiological functions of synaptic transmission.