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Table 2 Biomaterials used in the treatment of stroke

From: Ischemic stroke and repair: current trends in research and tissue engineering treatments

Materials

Species

Model

Effects

Functional recovery

Refs.

HAMC + PLGA + EGF-PEG + EPO

Mouse

Endothelin-1 induced small cortical infarcts

Led to neural tissue repair

N.A.

[68]

PLGA-PEG + T3

Mouse

MCAO

A 34% decrease in tissue infarction and a 59% decrease in brain edema

N.A.

[69]

Collagen type I + NSCs

Rat

MCAO

NSCs survived, differentiated and formed synapses in the brain

Function outcome is improved in neurological severity score

[70]

Hyaluronan-Heparin-Collagen + neural progenitor cells (NPCs)

Mouse

Photochemically induced cerebral ischemic

Promoted survival of NPCs and diminished the infiltration of Microglia/Macrophage cells

N.A.

[71]

Alginate + VEGF

Rat

MCAO

Reduced the lesion volume

Function outcome is improved in bias swing test and neurological severity score

[72]

PLGA + hNSCs + VEGF

Rat

MCAO

Attracted host endothelial cells (ECs) and developed a vascular network within de novo tissue

N.A.

[22]

HAMC + EPO

Mouse

Endothelin-1 induced small cortical infarc

Attenuated inflammatory responses; reduced stroke cavity size; increased the number of neurons and decreased apoptosis

N.A.

[73]

Hyaluronic-Acid(HA)-based hydrogel + Nogo-66 receptor (NgR)

Rat

MCAO

Supported cell migration, development and neural regeneration in the brain

Ameliorated the disabled function of the impaired forelimb

[74]

PGA + NSCs

Mouse

Hypoxia induced ischemic

Promoted neuronal differentiation; enhanced elaboration of neural processes; fostered re-formation of cortical tissue and reduced inflammation and scarring

N.A.

[75]