From: Ischemic stroke and repair: current trends in research and tissue engineering treatments
Materials | Species | Model | Effects | Functional recovery | Refs. |
---|---|---|---|---|---|
HAMC + PLGA + EGF-PEG + EPO | Mouse | Endothelin-1 induced small cortical infarcts | Led to neural tissue repair | N.A. | [68] |
PLGA-PEG + T3 | Mouse | MCAO | A 34% decrease in tissue infarction and a 59% decrease in brain edema | N.A. | [69] |
Collagen type I + NSCs | Rat | MCAO | NSCs survived, differentiated and formed synapses in the brain | Function outcome is improved in neurological severity score | [70] |
Hyaluronan-Heparin-Collagen + neural progenitor cells (NPCs) | Mouse | Photochemically induced cerebral ischemic | Promoted survival of NPCs and diminished the infiltration of Microglia/Macrophage cells | N.A. | [71] |
Alginate + VEGF | Rat | MCAO | Reduced the lesion volume | Function outcome is improved in bias swing test and neurological severity score | [72] |
PLGA + hNSCs + VEGF | Rat | MCAO | Attracted host endothelial cells (ECs) and developed a vascular network within de novo tissue | N.A. | [22] |
HAMC + EPO | Mouse | Endothelin-1 induced small cortical infarc | Attenuated inflammatory responses; reduced stroke cavity size; increased the number of neurons and decreased apoptosis | N.A. | [73] |
Hyaluronic-Acid(HA)-based hydrogel + Nogo-66 receptor (NgR) | Rat | MCAO | Supported cell migration, development and neural regeneration in the brain | Ameliorated the disabled function of the impaired forelimb | [74] |
PGA + NSCs | Mouse | Hypoxia induced ischemic | Promoted neuronal differentiation; enhanced elaboration of neural processes; fostered re-formation of cortical tissue and reduced inflammation and scarring | N.A. | [75] |