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Table 2 Biomaterials used in the treatment of stroke

From: Ischemic stroke and repair: current trends in research and tissue engineering treatments

Materials Species Model Effects Functional recovery Refs.
HAMC + PLGA + EGF-PEG + EPO Mouse Endothelin-1 induced small cortical infarcts Led to neural tissue repair N.A. [68]
PLGA-PEG + T3 Mouse MCAO A 34% decrease in tissue infarction and a 59% decrease in brain edema N.A. [69]
Collagen type I + NSCs Rat MCAO NSCs survived, differentiated and formed synapses in the brain Function outcome is improved in neurological severity score [70]
Hyaluronan-Heparin-Collagen + neural progenitor cells (NPCs) Mouse Photochemically induced cerebral ischemic Promoted survival of NPCs and diminished the infiltration of Microglia/Macrophage cells N.A. [71]
Alginate + VEGF Rat MCAO Reduced the lesion volume Function outcome is improved in bias swing test and neurological severity score [72]
PLGA + hNSCs + VEGF Rat MCAO Attracted host endothelial cells (ECs) and developed a vascular network within de novo tissue N.A. [22]
HAMC + EPO Mouse Endothelin-1 induced small cortical infarc Attenuated inflammatory responses; reduced stroke cavity size; increased the number of neurons and decreased apoptosis N.A. [73]
Hyaluronic-Acid(HA)-based hydrogel + Nogo-66 receptor (NgR) Rat MCAO Supported cell migration, development and neural regeneration in the brain Ameliorated the disabled function of the impaired forelimb [74]
PGA + NSCs Mouse Hypoxia induced ischemic Promoted neuronal differentiation; enhanced elaboration of neural processes; fostered re-formation of cortical tissue and reduced inflammation and scarring N.A. [75]