Current status of induced pluripotent stem cells in cardiac tissue regeneration and engineering

Table 2 Cardiac differentiation from iPSCs

Induce medium OR supplement	Species	Efficiency	Differentiation manner	Ref.
IMDM	Mice	~55% beating EBs	EB formation	[16]
α-MEM and coculture	Mice	Unclear	Direct differentiation	[74]
DMEM/F12	Human	~10% beating or bellow	EB formation	[17]
α-MEM	Human	Unclear	EB formation	[79]
DMEM	Human	Unclear	EB formation	[80]
5-AZ or BMP-4 or DMSO	Human	23.7% of cells by 5-AZ	EB formation	[81]
IMDM	Murine	Unclear	EB formation	[82]
Ascorbic acid	Mice; human	Unclear	Through Isl1(+) progenitors	[83]
IMDM	Mice	Unclear	EB formation	[84]
DMEM and coculture on END2 cells	Human	~12.8±3.5% beating EBs	Cell clumps	[85]
TSA	Mice	Unclear	Direct differentiation	[77]
FGF-10	Mice	Unclear	EB formation	[86]
RPMI+B27 (+Activin A/BMP4/bFGF)	Human	30-70% Beating EBs	Monolayer culture	[75]
Cyclosporin-A	Mice	Unclear	Through Flk1+ cells	[87]
DMEM	Mice	Unclear	EB formation	[88]
Insulin+ BMP4+FGF2	Human	>90%	EB formation	[76]
Sulfonyl-hydrazone-1	Mice	Unclear	EB formation	[89]
DMEM, EBM-2	Mice	~44.8%	EB formation	[90]
Stem Pro-34 medium + ascorbic acid + PenStrep + monothioglycerol + Activin A + BMP4 + bFGF	Human	More than 50%	Direct differentiation as a monolayer	[78]

ISSN: 2050-490X