Table 1 Cysteinyl cathepsins and AAA
From: Cathepsins: a new culprit behind abdominal aortic aneurysm
Cathepsins | Role in AAA |
|---|---|
Cathepsin G inhibition | Suppress elastase activaty, enhance aorta stability, reduce vessel damage |
Cathepsin K knockout | Decrease T lymphocyte migration, neovascularization, MMP expression, and cathepsin activation |
Cathepsin L knockout | Lower the number of macrophages and decrease T lymphocyte migration, neovascularization, MMP expression, and cathepsin activation |
Cathepsin S knockout | Damage elastin integrity, increase collagen accumulation, lower the number of macrophages |