Table 1 Epidemiologic and clinical data of the different groups of heart donors
From: Insulin-like growth factor 1 myocardial expression decreases in chronic alcohol consumption
Control donors (n=10) | Hypertensive donors (n=16) | Alcoholic donors (n=23) | Donors with other causes of cardiac disease (n=7) | |
|---|---|---|---|---|
Age (y; mean (SD)) | 52.3 (22.1) | 62.1 (10.7) | 54.3 (10.0) | 59.1 (13.8) |
Male/female ratio (n) | 3:7 | 8:8 | 19:4 | 6:1 |
Daily alcohol intake (g; mean (SD)) | 0 | 10.7 (19.4) | 148.2 (54.9)*** | 8.6 (22.8) |
Lifetime dose of ethanol (kg ethanol/kg body weight; mean (SD)) | 0 | 0.54 (0.2) | 15.5 (8.3)*** | 0.77 (0.2) |
Active smokers [n (%)] | 1 (10) | 4 (25) | 17 (74)*** | 2 (29) |
Time from admission to donation (h; mean (SD)) | 30 (2) | 30 (3) | 33 (2) | 30 (2) |
NYHA function [n (%)] | ||||
Class I | 10 (100) | 11 (68) | 12 (51) | 4 (57) |
Class II | 0 | 4 (26) | 7 (30) | 2 (29) |
Classes III and IV | 0 | 1 (6) | 2 ( 9) | 1 (14) |
Cardiothoracic index (mean (SD)) | 0.47 (0.01) | 0.54 (0.05)** | 0.54 (0.05)** | 0.58 (0.05)** |
Electrocardiogram [abnormal cases; n (%)] | 1 (10) | 11 (69)* | 10 (43)** | 7 (100)* |
Left ventricular ejection fraction (%; mean (SD)) | 61 (3) | 45 (9)** | 45 (7)** | 41 (7)** |
End-diastolic diameter (mm; mean (SD)) | 46.6 (2.2) | 52.5 (5.1) ** | 58.4 (6.2) ** | 59.6 (6.4) ** |
End-systolic diameter (mm; mean (SD)) | 29.7 (2.9) | 38.3 (3.8) ** | 43.8 (5.7) ** | 45.4 (6.2) ** |
Left ventricular mass (g/m2; mean (SD)) | 107 (6) | 139 (10) ** | 143 (11) ** | 146 (13) ** |
Cell hypertrophy [n (%)] | 0 (0) | 11 (69) ** | 17 (74) ** | 7 (100) ** |
Nuclear hypertrophy [n (%)] | 0 (0) | 14 (88) ** | 19 (82) ** | 7 (100) ** |