Figure 5

Recovery of TA fiber area is delayed following muscle injury in alcohol-fed mice. (A) Regardless of diet, regenerating muscle fibers are smaller than their uninjured, contralateral TA areas. Moreover, regenerating fibers from alcohol-fed mice are smaller than those from alcohol-naïve mice. (B) In control-fed mice, regenerating fibers are similar in cross-sectional area as the uninjured, contralateral TA muscles 14 days after injury. In contrast, regenerating fibers from alcohol-fed mice are still smaller than alcoholic, uninjured muscle. This suggests that regeneration in the presence of continued alcohol ingestion delays skeletal muscle repair following injury. Significance was accepted at p ≤ 0.05. *, compared to control-fed, uninjured group. #, compared to EtOH-fed, uninjured group.