Figure 4

Representative histology of regenerating TA muscles following injury in alcohol-fed mice. The processes of skeletal muscle injury and repair in TA muscles from control-fed mice are displayed in panels (A) uninjured muscle, and (C) 2 days, (E) 7 days, and (G) 14 days following BaCl₂ injection. Similarly, muscle regeneration in alcohol-fed mice is displayed in panels (B) uninjured muscle, and (D) 2 days, (F) 7 days, and (H) 14 days following BaCl₂ injection. Arrow heads in panels F and H denote areas of increased interstitial tissue accumulation and fibrosis in regenerating muscle from alcohol-fed mice. Cross-sectional areas of regenerating fibers, as noted by the presence of centralized nuclei shown in panels E-H, have been quantified in Figure 4. Bar in panel H = 100μm.